Predictable control of RNA lifetime using engineered degradation-tuning RNAs

June 21st, 2021 by Qi Zhang

Nature Chemical Biology, Published online: 21 June 2021; doi:10.1038/s41589-021-00816-4

Degradation-tuning RNAs (dtRNAs) have the capacity to increase and decrease RNA stability in vivo and in vitro. Appending these modules to transcripts allows fine tuning of circuit dynamics, CRISPR interference and paper-based viral diagnostics.
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