Chaperones convert the energy from ATP into the nonequilibrium stabilization of native proteins
March 5th, 2018 by Pierre Goloubinoff
Chaperones convert the energy from ATP into the nonequilibrium stabilization of native proteins
Chaperones convert the energy from ATP into the nonequilibrium stabilization of native proteins, Published online: 05 March 2018; doi:10.1038/s41589-018-0013-8
A nonequilibrium thermodynamic model can explain how molecular chaperones such as GroEL can use the energy from ATP hydrolysis to maintain substrate proteins in an active state, even under conditions that favor the substrate’s inactive unfolded state.