Development of targeted protein degradation therapeutics

September 16th, 2019 by Philip P. Chamberlain

Nature Chemical Biology, Published online: 16 September 2019; doi:10.1038/s41589-019-0362-y

This Perspective summarizes recent discoveries that have laid the foundation for targeted degradation therapeutics and discusses the current state of understanding and consideration involved in developing these protein degraders.

Linkers for protein degradation

June 11th, 2018 by Philip P. Chamberlain

Linkers for protein degradation

Linkers for protein degradation, Published online: 11 June 2018; doi:10.1038/s41589-018-0057-9

The ability to subvert E3 ubiquitin ligases with small-molecule drugs offers tremendous promise for drug discovery. A new study demonstrates how structural and computational techniques can engineer and exploit unnatural protein–protein interfaces to design selective protein degraders.