Interhelical interactions within the STIM1 CC1 domain modulate CRAC channel activation
October 26th, 2020 by Petr Rathner
Nature Chemical Biology, Published online: 26 October 2020; doi:10.1038/s41589-020-00672-8
The helical bundle structure of the CC1 domain of STIM1 of the store-activated calcium channel CRAC is crucial to maintaining the channel resting state, and helix–helix interactions can be manipulated to normalize a disease-linked STIM1 mutant.