Peroxisome compartmentalization of a toxic enzyme improves alkaloid production
October 12th, 2020 by Parbir S. Grewal
Nature Chemical Biology, Published online: 12 October 2020; doi:10.1038/s41589-020-00668-4
Increased production of (S)-reticuline and other alkaloids is achieved through alleviating norcoclaurine synthase toxicity by targeting the enzyme to the peroxisome plus enlarging peroxisomes by expression of engineered transcription factors.