Discovery of an antivirulence compound that reverses <i>β</i>-lactam resistance in MRSA
November 25th, 2019 by Omar M. El-Halfawy
Nature Chemical Biology, Published online: 25 November 2019; doi:10.1038/s41589-019-0401-8
A potent inhibitor of the MRSA virulence regulator, GraR, reverses methicillin resistance, inhibits biofilm formation, limits bacterial survival in macrophages and attenuates virulence in vitro, synergizing with cationic antimicrobial peptides.