Defective Hydrophobic Sliding Mechanism and Active Site Expansion in HIV-1 Protease Drug Resistant Variant Gly48Thr/Leu89Met: Mechanisms for the Loss of Saquinavir Binding Potency

January 7th, 2015 by Nathan E. Goldfarb, Meray Ohanessian, Shyamasri Biswas, T. Dwight McGee, Brian P. Mahon, David A. Ostrov, Jose Garcia, Yan Tang, Robert McKenna, Adrian Roitberg and Ben M. Dunn

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DOI: 10.1021/bi501088e