Neuroinflammation: Modulating mighty microglia

November 13th, 2014 by Michelle L Block

Nature Chemical Biology 10, 988 (2014). doi:10.1038/nchembio.1691

Author: Michelle L Block

The small molecule inflachromene was discovered as a microglia-selective inhibitor of the central nervous system proinflammatory response and found to target HMGB2 and HMGB1 to impair proinflammatory signaling in microglia, resulting in neuroprotection.