Carbohydrates: Translation from sticky to sweet

March 18th, 2015 by Michela G Tonetti

Nature Chemical Biology 11, 243 (2015). doi:10.1038/nchembio.1773

Author: Michela G Tonetti

Bacterial translation elongation factor P (EF-P) is essential to overcome ribosome stalling at polyproline stretches during protein synthesis. A new mechanism of EF-P activation, identified in a subset of Bacteria, involves addition of the sugar L-rhamnose to a critical arginine residue.