An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel
March 19th, 2018 by Michaela Lichtenegger
An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel
An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel, Published online: 19 March 2018; doi:10.1038/s41589-018-0015-6
A photoswitchable diacylglycerol enabled a screen that found critical TRPC3 lipid-sensing residues and identified a lateral fenestration in the pore domain that allows lipids to protrude into the permeation pathway to control channel gating.