Inhibition of Delta-induced Notch signaling using fucose analogs
November 27th, 2017 by Michael Schneider
Inhibition of Delta-induced Notch signaling using fucose analogs
Inhibition of Delta-induced Notch signaling using fucose analogs, Published online: 27 November 2017; doi:10.1038/nchembio.2520
Protein O-fucosyltransferase 1 (Pofut1) regulates Notch activity by adding O-fucose residues to its extracellular domain. Fucose analogs were identified that inhibited Delta-mediated Notch binding and activation but spared Jagged1-mediated signaling.