FINO<sub>2</sub> initiates ferroptosis through GPX4 inactivation and iron oxidation
April 2nd, 2018 by Michael M. Gaschler
FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation
FINO<sub>2</sub> initiates ferroptosis through GPX4 inactivation and iron oxidation, Published online: 02 April 2018; doi:10.1038/s41589-018-0031-6
FINO2 is a small molecule that requires the endoperoxide moiety and hydroxyl group to promote ferroptosis through indirect inhibition of GPX4 enzymatic function and direct oxidation of iron, resulting in increased lipid peroxidation.