Introduction to Thematic Minireview Series: Novel Bioactive Sphingolipids [Metabolism]

May 6th, 2015 by Merrill, A. H., Carman, G. M.

Sphingosine was named by J. L. W. Thudichum for its enigmatic properties. This descriptor has applied to sphingolipids for over a century because new enigmas continue to surface. This JBC minireview series presents articles about three novel subspecies of sphingolipids-- α-galactosylceramides, 4,5-dihydroceramides and 1-deoxysphingolipids-- that have important activities but, until recently, remained undetected (or at least understudied) in the shadow of very closely related compounds. They also serve as a reminder that important metabolites still lie "off the radar screen" in reports of global and comprehensive metabolomic profiling.