Mechanical strength of RNA knot in Zika virus protects against cellular defenses

July 12th, 2021 by Meng Zhao

Nature Chemical Biology, Published online: 12 July 2021; doi:10.1038/s41589-021-00829-z

A knot-like RNA from Zika virus is shown to evade digestion by host RNases through its extreme resistance to mechanical unfolding. Weakening the knot mechanically or reducing the likelihood of knot formation lowers the RNase resistance.
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