Dynamic membrane topology in an unassembled membrane protein

September 9th, 2019 by Maximilian Seurig

Nature Chemical Biology, Published online: 09 September 2019; doi:10.1038/s41589-019-0356-9

The topology of homodimeric membrane protein EmrE is dynamic and includes unassisted flipping of an N-terminal helix in and out of the membrane long after co-translational insertion. Dimerization locks the helix to limit topological dynamics.