Stick it to E3s

June 17th, 2019 by Matthias Brand

Nature Chemical Biology, Published online: 17 June 2019; doi:10.1038/s41589-019-0312-8

The limited availability of small-molecule ligands for E3 ubiquitin ligases stymies the development of next-generation degraders. Two recent papers report the identification of novel, covalent and PROTAC-compatible ligands that hijack the previously untargeted ligases RNF114 and DCAF16.