Imaging and targeting LOX-mediated tissue remodeling with a reactive collagen peptide
July 12th, 2021 by Matthew R. Aronoff
Nature Chemical Biology, Published online: 12 July 2021; doi:10.1038/s41589-021-00830-6
Collagen cross-linking, mediated by lysyl oxidases (LOX), is critical for the stability of the extracellular matrix. Aldehyde-reactive sensors and collagen peptide probes for monitoring LOX activity enable direct in vivo imaging of collagen maturation.