Addendum: Cryptic phosphorylation in nucleoside natural product biosynthesis
August 11th, 2021 by Matthew M. Draelos
Nature Chemical Biology, Published online: 11 August 2021; doi:10.1038/s41589-021-00867-7
Addendum: Cryptic phosphorylation in nucleoside natural product biosynthesisCryptic phosphorylation in nucleoside natural product biosynthesis
November 30th, 2020 by Matthew M. Draelos
Nature Chemical Biology, Published online: 30 November 2020; doi:10.1038/s41589-020-00656-8
Rather than their expected role in self-immunity, kinases encoded in the biosynthetic gene clusters of nucleoside natural products catalyze the phosphorylation of an early intermediate, a modification that is later removed in a downstream step.