Sulfated glycans engage the Ang–Tie pathway to regulate vascular development
October 5th, 2020 by Matthew E. Griffin
Nature Chemical Biology, Published online: 05 October 2020; doi:10.1038/s41589-020-00657-7
A chemical glycobiology approach reveals that heparan-sulfate glycosaminoglycans regulate vascular development through direct interactions with angiopoietin (Ang) ligands and the Tie1 receptor of the Ang–Tie signaling system.