Dynamic assembly of protein disulfide isomerase in catalysis of oxidative folding
April 15th, 2019 by Masaki Okumura
Dynamic assembly of protein disulfide isomerase in catalysis of oxidative folding
Dynamic assembly of protein disulfide isomerase in catalysis of oxidative folding, Published online: 15 April 2019; doi:10.1038/s41589-019-0268-8
Single-molecule analysis by high-speed atomic force microscopy reveals that oxidized protein disulfide isomerase adopts a dynamic conformation in the absence of substrates and forms face-to-face dimers to accelerate oxidative folding in the presence of substrates.