Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic
April 16th, 2018 by Marina Santiago
Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic
Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic, Published online: 16 April 2018; doi:10.1038/s41589-018-0041-4
Use of a combined Tn-seq and machine-learning approach for predicting mechanisms and targets of antibiotic action in Staphylococcus aureus shows that the natural product lysocin E (LysE) binds Lipid II on the cell surface and damages the membrane.