Metabolism: Jump-starting CoA biosynthesis

September 17th, 2015 by Marianne de Villiers

Nature Chemical Biology 11, 757 (2015). doi:10.1038/nchembio.1912

Authors: Marianne de Villiers & Erick Strauss

The essential metabolic cofactor coenzyme A was believed to be produced by biosynthesis from pantothenate in all eukaryotic cells. Rescue experiments in systems depleted of CoA have shown that a phosphorylated CoA biosynthetic intermediate can pass through eukaryotic membranes to serve as an alternative source.