Drug selectivity: Running in the family

July 6th, 2014 by Marcel Muelbaier

Nature Chemical Biology 10, 608 (2014). doi:10.1038/nchembio.1585

Authors: Marcel Muelbaier & Gerard Drewes

Comprehensive selectivity profiling is key for the development of safe drugs. Few current methods are capable of profiling large compound sets against entire target classes. The new EnPlex method expands the existing toolbox, allowing for the surveying of the serine hydrolase enzyme family.