Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering

May 6th, 2021 by Lian He

Nature Chemical Biology, Published online: 06 May 2021; doi:10.1038/s41589-021-00792-9

A set of LOV2 circular permutants (cpLOV2) have been engineered to expand the existing optogenetic toolbox. cpLOV2 enables the design of both ON- and OFF-switches to control cell signaling, gene expression, cell fate and cancer immunotherapy.
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