Lipids lead the way

June 20th, 2019 by Leslie N. Aldrich

Nature Chemical Biology, Published online: 20 June 2019; doi:10.1038/s41589-019-0309-3

Autophagy is a ‘self-eating’ recycling process that maintains cellular homeostasis. Autogramins were identified as small-molecule autophagy inhibitors that target the cholesterol transport protein GRAMD1A, revealing a role for cholesterol in autophagosome biogenesis.