Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains

March 11th, 2021 by Laurence Abrami

Nature Chemical Biology, Published online: 11 March 2021; doi:10.1038/s41589-021-00753-2

Acyl protein thioesterase APT2 interacts with membranes via its charged β-tongue, becomes palmitoylated by ZDHHC3/7 and deforms the bilayer to extract substrate acyl chains. APT2 deacylation leads to its membrane release and degradation.
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