Target engagement: Shining a light
January 19th, 2017 by Kilian V M Huber
Nature Chemical Biology 13, 133 (2017). doi:10.1038/nchembio.2295
Author: Kilian V M Huber
The ability to measure the binding of a compound to its intended target in live cells or tissue is a critical parameter for drug discovery. A new method using polarized light microscopy adds to the current toolbox by enabling monitoring of target engagement in vitro and in vivo at single-cell resolution.