Molecular glue concept solidifies

December 9th, 2019 by Kheewoong Baek

Nature Chemical Biology, Published online: 09 December 2019; doi:10.1038/s41589-019-0414-3

Molecular-glue-mediated proximity-induced degradation now allows unprecedented therapeutic targeting of previously undruggable proteins. Structures showing how aryl-sulfonamides mediate recruitment of the splicing factor RBM39 to the E3 CRL4DCAF15 broaden the mechanistic principles by which molecular glues target ubiquitylation.