Glutamate receptors: Mechanistic twists and turns

August 18th, 2014 by Kasper B Hansen

Nature Chemical Biology 10, 698 (2014). doi:10.1038/nchembio.1614

Authors: Kasper B Hansen & Stephen F Traynelis

Ionotropic glutamate receptors are ligand-gated ion channels that mediate excitatory neurotransmission, which is crucial for memory and learning. New cryo-electron microscopy structures of these receptors trapped in distinct functional states provide remarkable insight into conformational changes triggered by agonist binding.