Glycobiology: Drifting toward polymer perfection

April 13th, 2014 by Karen J Colley

Nature Chemical Biology 10, 410 (2014). doi:10.1038/nchembio.1506

Author: Karen J Colley

The addition of polysialic acid to proteins and cells is emerging as a promising therapeutic strategy. Polysialyltransferases synthesize polymers of widely varying lengths not optimal for therapeutic reagents, but the development of enzyme variants using neutral genetic drift offers a new way to overcome this problem.