DNA replication: Unlocking the secrets of fork arrest

July 6th, 2015 by Jun Fan

Nature Chemical Biology 11, 550 (2015). doi:10.1038/nchembio.1860

Authors: Jun Fan & Terence R Strick

A powerful, high-throughput single-molecule approach to probe the nanoscale mechanical properties of the Tus–Ter protein–DNA complex reveals that the Tus–Ter-induced lock in unzipping at the nonpermissive face requires only DNA strand separation and involves a progressive strengthening of the Tus–Ter complex.