Mechanistic insights revealed by a UBE2A mutation linked to intellectual disability
December 10th, 2018 by Juliana Ferreira de Oliveira
Mechanistic insights revealed by a UBE2A mutation linked to intellectual disability
Mechanistic insights revealed by a UBE2A mutation linked to intellectual disability, Published online: 10 December 2018; doi:10.1038/s41589-018-0177-2
Structural and biochemical analysis of a UBE2A mutation linked to intellectual disability reveals that the Q93E mutant perturbs the E2 catalytic microenvironment essential for lysine deprotonation during the ubiquitin-transfer process.