Protein trafficking: RESETting proteostasis

October 17th, 2014 by Julia Noack

Nature Chemical Biology 10, 881 (2014). doi:10.1038/nchembio.1652

Authors: Julia Noack & Maurizio Molinari

A recent study reveals a new cellular pathway that clears the endoplasmic reticulum of misfolded, GPI-anchored proteins at the onset of endoplasmic reticulum (ER) stress. This mechanism, termed rapid ER stress–induced export, represents a nontranscriptional response to mitigate acute ER stress.