Stapled peptides: How to be quick on the uptake

September 20th, 2016 by Joshua A Kritzer

Nature Chemical Biology 12, 764 (2016). doi:10.1038/nchembio.2183

Author: Joshua A Kritzer

Stapled helices are promising compounds for inhibiting intracellular protein–protein interactions, but the discovery of peptides with the key property of cellular uptake has taken place largely through trial and error. A new study defines physicochemical parameters for designing hydrocarbon-stapled helices with a greater likelihood of cellular uptake.