Lysosome-targeting chimeras evolve

August 19th, 2021 by Joshiawa Paulk

Nature Chemical Biology, Published online: 19 August 2021; doi:10.1038/s41589-021-00835-1

LYTACs induce selective degradation of extracellular proteins by recruiting them to cellular receptors that mediate delivery to the lysosome. Recent development of GalNAc-LYTACs and MoDE-As targeting the liver-specific ASGPR enables cell-type-restricted lysosomal protein degradation and reveals new LYTAC design principles.