Protein aggregation: A rescue by chaperones

January 19th, 2016 by Joost Schymkowitz

Nature Chemical Biology 12, 58 (2016). doi:10.1038/nchembio.2006

Authors: Joost Schymkowitz & Frederic Rousseau

Protein aggregation is associated with more than 50 human pathologies, including prevalent conditions such as Alzheimer's and Parkinson's diseases. A phenotypic screen in Escherichia coli associating antibiotic resistance with the inhibition of protein aggregation now allows screening for chemical inhibitors of protein aggregation in a simple, fast and inexpensive manner.