Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler
December 7th, 2020 by Joanna Liwocha
Nature Chemical Biology, Published online: 07 December 2020; doi:10.1038/s41589-020-00696-0
Using synthetic ubiquitins with non-natural acceptor site, the authors revealed that the length of lysine side chain in acceptor ubiquitins affects ubiquitin chain linkage specificity with native lysine as the preferred geometry.