Neuronal differentiation: 5-HT6R can do it alone

June 17th, 2014 by Jinsoo Seo

Nature Chemical Biology 10, 488 (2014). doi:10.1038/nchembio.1557

Authors: Jinsoo Seo & Li-Huei Tsai

A study in this issue reports the 5-HT6 receptor as a new cyclin-dependent kinase 5 (Cdk5) substrate and reveals its noncanonical pathway, which mediates neuronal differentiation in hippocampus and striatum by interacting with Cdk5 and Cdc42 in an agonist-independent manner.