Sweetly profiling the cysteinome

August 5th, 2019 by Jing Yang

Nature Chemical Biology, Published online: 05 August 2019; doi:10.1038/s41589-019-0348-9

A new sugar-based cysteine-reactive probe, combined with competitive activity-based protein profiling (ABPP), enables site-centric target deconvolution of itaconate in native proteomes, shedding light on a novel mechanism of action for this important immunoregulatory metabolite in inflammatory macrophages.