Suicide inactivation of the uracil DNA glycosylase UdgX by covalent complex formation
May 17th, 2019 by Jie Tu
Nature Chemical Biology, Published online: 17 May 2019; doi:10.1038/s41589-019-0290-x
Structural analysis of uracil DNA glycosylase reveals that its high affinity with DNA substrates derives from a stable intermediate that is formed by conservative H109 in a protruding loop covalently binding to the abasic site after uracil is excised.