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Rational design of proteins that exchange on functional timescales

October 23rd, 2017 by James A Davey

Rational design of proteins that exchange on functional timescales

Rational design of proteins that exchange on functional timescales, Published online: 23 October 2017; doi:10.1038/nchembio.2503

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The development of a computational protein design method, meta-multistate design, enables the design and validation of protein variants termed DANCERs that spontaneously exchange between predicted conformational states on the millisecond timescale.

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