p63 uses a switch-like mechanism to set the threshold for induction of apoptosis
July 27th, 2020 by Jakob Gebel
Nature Chemical Biology, Published online: 27 July 2020; doi:10.1038/s41589-020-0600-3
TAp63α monitors the genome integrity in oocytes. After DNA damage, TAp63α is activated, involving multiple phosphorylation steps by CK1 with different kinetics due to an unusual CK1/TAp63α interaction in which the product of one step inhibits the next.