Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel
June 29th, 2020 by Ilya A. Osterman
Nature Chemical Biology, Published online: 29 June 2020; doi:10.1038/s41589-020-0578-x
Structural and biochemical analysis reveal that tetracenomycin X acts as an inhibitor of protein synthesis by binding within the exit tunnel in a large ribosomal unit to prevent the prolongation of the nascent polypeptide chain.