Extracellular phosphorylation drives the formation of neuronal circuitry
August 26th, 2019 by Hidekiyo Harada
Nature Chemical Biology, Published online: 26 August 2019; doi:10.1038/s41589-019-0345-z
Via its receptor LRP5, Wnt3a stimulates axonal growth in retinal ganglion neurons. Phosphorylation of co-receptor RGMb by VLK induces LRP5 internalization to limit Wnt3a signaling and reduce axon growth.