A giant ubiquitin ligase

August 3rd, 2021 by Hidde Ploegh

Nature Chemical Biology, Published online: 03 August 2021; doi:10.1038/s41589-021-00860-0

The structure of a giant ubiquitin E3 ligase sheds light on its activation in a substrate-dependent manner and shows how a single E3 enzyme uses distinct recognition modules to confer substrate specificity.