Metabolic engineering of a carbapenem antibiotic synthesis pathway in <i>Escherichia coli</i>
June 25th, 2018 by Helena Shomar
Metabolic engineering of a carbapenem antibiotic synthesis pathway in Escherichia coli
Metabolic engineering of a carbapenem antibiotic synthesis pathway in <i>Escherichia coli</i>, Published online: 25 June 2018; doi:10.1038/s41589-018-0084-6
Efficient production of a simple carbapenem antibiotic in Escherichia coli is achieved by a combination of feedback-resistant enzymes for increased precursor biosynthesis and inhibition of fatty acid synthesis for tolerance toward the toxic product.