Phospholipids: A neuroinflammation emerging target

January 20th, 2015 by Hee-Yong Kim

Nature Chemical Biology 11, 99 (2015). doi:10.1038/nchembio.1740

Author: Hee-Yong Kim

Lysophosphatidylserines (lyso-PSs) are an emerging class of signaling lipids implicated in human inflammatory and autoimmune diseases. A newly discovered phosphatidylserine-specific lipase, ABHD16A, together with the recently described lyso-PS lipase ABHD12 shed light on the in vivo regulation of lyso-PS, providing a potential enzymatic target for modulating neuroinflammatory responses.