Enzyme regulation: A thiol switch opens the gate

November 10th, 2014 by Haike Antelmann

Nature Chemical Biology 11, 4 (2015). doi:10.1038/nchembio.1698

Author: Haike Antelmann

AAA+ proteases are quality control machineries consisting of substrate-binding ATPase modules for protein unfolding and a proteolytic chamber. New research now shows a redox switch in the Escherichia coli Lon protease that controls this process, widening the exit pore and activating proteolysis during transition from anaerobic to aerobic environments.