Chaperones: Speedy motion for function

July 19th, 2016 by Hagen Hofmann

Nature Chemical Biology 12, 576 (2016). doi:10.1038/nchembio.2130

Author: Hagen Hofmann

Hsp90 is an energy-consuming molecular chaperone that activates oncogenic proteins in a complicated multi-step reaction. Photoinduced electron transfer (PET) quenching experiments with a fluorescent reporter have now identified molecular transitions at multiple timescales in the chaperone cycle of Hsp90.