Reversal of nucleobase methylation by dioxygenases

October 16th, 2020 by Guo-Liang Xu

Nature Chemical Biology, Published online: 16 October 2020; doi:10.1038/s41589-020-00675-5

This Review summarizes the chemical and physical properties of methylated nucleobases in DNA and RNA, proposes a chemical classification of methylation types, and discusses recent advance in demethylation reactions mediated by dioxygenases.